Publication: Co-option of membrane wounding enables virus penetration into cells
Co-option of membrane wounding enables virus penetration into cells
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Luisoni, S., Suomalainen, M., Boucke, K., Tanner, L. B., Wenk, M. R., Guan, X. L., Grzybek, M., Coskun, Ü., & Greber, U. F. (2015). Co-option of membrane wounding enables virus penetration into cells. Cell Host & Microbe, 18, 75–85. https://doi.org/10.1016/j.chom.2015.06.006
Abstract
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Abstract
During cell entry, non-enveloped viruses undergo partial uncoating to expose membrane lytic proteins for gaining access to the cytoplasm. We report that adenovirus uses membrane piercing to induce and hijack cellular wound removal processes that facilitate further membrane disruption and infection. Incoming adenovirus stimulates calcium influx and lysosomal exocytosis, a membrane repair mechanism resulting in release of acid sphingomyelinase (ASMase) and degradation of sphingomyelin to ceramide lipids in the plasma membrane. Lysosomal
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- Luisoni, Stefania
- Suomalainen, Maarit
- Boucke, Karin
- Tanner, Lukas B
- Wenk, Markus R
- Guan, Xue Li
- Grzybek, Michał
- Coskun, Ünal
- Greber, Urs F
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Luisoni, S., Suomalainen, M., Boucke, K., Tanner, L. B., Wenk, M. R., Guan, X. L., Grzybek, M., Coskun, Ü., & Greber, U. F. (2015). Co-option of membrane wounding enables virus penetration into cells. Cell Host & Microbe, 18, 75–85. https://doi.org/10.1016/j.chom.2015.06.006
