Juice of Bryophyllum pinnatum (Lam.) inhibits oxytocin-induced increase of the intracellular calcium concentration in human myometrial cells

Simões-Wüst, Ana Paula; Grãos, M; Duarte, C B; Brenneisen, R; Hamburger, M; Mennet, M; Ramos, M H; Schnelle, M; Wächter, R; Worel, A M; von Mandach, U

doi:10.1016/j.phymed.2010.03.005

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Simões-Wüst, A. P., Grãos, M., Duarte, C. B., Brenneisen, R., Hamburger, M., Mennet, M., Ramos, M. H., Schnelle, M., Wächter, R., Worel, A. M., & von Mandach, U. (2010). Juice of Bryophyllum pinnatum (Lam.) inhibits oxytocin-induced increase of the intracellular calcium concentration in human myometrial cells. Phytomedicine, 17, 980–986. https://doi.org/10.1016/j.phymed.2010.03.005

Abstract

The use of preparations from Bryophyllum pinnatum in tocolysis is supported by both clinical (retrospective comparative studies) and experimental (using uterus strips) evidence. We studied here the effect of B. pinnatum juice on the response of cultured human myometrial cells to stimulation by oxytocin, a hormone known to be involved in the control of uterine contractions by increasing the intracellular free calcium concentration ([Ca2+]i). In this work, [Ca2+]i was measured online during stimulation of human myometrial cells (hTERT-C