Publication: Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing
Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing
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Paliwal, S., Kanagaraj, R., Sturzenegger, A., Burdova, K., & Janscak, P. (2014). Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing. Nucleic Acids Research, 42, 2380–2390. https://doi.org/10.1093/nar/gkt1263
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Abstract
Most mitotic homologous recombination (HR) events proceed via a synthesis-dependent strand annealing mechanism to avoid crossing over, which may give rise to chromosomal rearrangements and loss of heterozygosity. The molecular mechanisms controlling HR sub-pathway choice are poorly understood. Here, we show that human RECQ5, a DNA helicase that can disrupt RAD51 nucleoprotein filaments, promotes formation of non-crossover products during DNA double-strand break-induced HR and counteracts the inhibitory effect of RAD51 on RAD52-mediate
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- Paliwal, Shreya
- Kanagaraj, Radhakrishnan
- Sturzenegger, Andreas
- Burdova, Kamila
- Janscak, Pavel
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Paliwal, S., Kanagaraj, R., Sturzenegger, A., Burdova, K., & Janscak, P. (2014). Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing. Nucleic Acids Research, 42, 2380–2390. https://doi.org/10.1093/nar/gkt1263
