Light stress affects cones and horizontal cells via rhodopsin-mediated mechanisms

Samardzija, Marijana; Todorova, Vyara; Gougoulakis, Laura; Barben, Maya; Nötzli, Sarah; Klee, Katrin; Storti, Federica; Gubler, Andrea; Imsand, Cornelia; Grimm, Christian

doi:10.1016/j.exer.2019.107719

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Samardzija, M., Todorova, V., Gougoulakis, L., Barben, M., Nötzli, S., Klee, K., Storti, F., Gubler, A., Imsand, C., & Grimm, C. (2019). Light stress affects cones and horizontal cells via rhodopsin-mediated mechanisms. Experimental Eye Research, 186, 107719. https://doi.org/10.1016/j.exer.2019.107719

Abstract

Retinal degenerations are a major cause of blindness in human patients. The identification of endogenous mechanisms involved in neurodegeneration or neuroprotection helps to understand the response of the retina to stress and provides essential information not only for basic retinal physiology but also for defining molecular targets for neuroprotective strategies. Here we used excessive light exposure as a model system to study mechanisms of photoreceptor degeneration in mice. Using one wild type and four genetically modified mouse st