Publication: Metabolism of myo-inositol by legionella pneumophila promotes infection of amoebae and macrophages
Metabolism of myo-inositol by legionella pneumophila promotes infection of amoebae and macrophages
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Manske, C., Schell, U., & Hilbi, H. (2016). Metabolism of myo-inositol by legionella pneumophila promotes infection of amoebae and macrophages. Applied and Environmental Microbiology, 82, 5000–5014. https://doi.org/10.1128/AEM.01018-16
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UNLABELLED Legionella pneumophila is a natural parasite of environmental amoebae and the causative agent of a severe pneumonia termed Legionnaires' disease. The facultative intracellular pathogen employs a bipartite metabolism, where the amino acid serine serves as the major energy supply, while glycerol and glucose are mainly utilized for anabolic processes. The L. pneumophila genome harbors the cluster lpg1653 to lpg1649 putatively involved in the metabolism of the abundant carbohydrate myo-inositol (here termed inositol). To assess
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- Manske, Christian
- Schell, Ursula
- Hilbi, Hubert
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Manske, C., Schell, U., & Hilbi, H. (2016). Metabolism of myo-inositol by legionella pneumophila promotes infection of amoebae and macrophages. Applied and Environmental Microbiology, 82, 5000–5014. https://doi.org/10.1128/AEM.01018-16
