Publication: Engineering of living autologous human umbilical cord cell-based septal occluder membranes using composite PGA-P4HB matrices
Engineering of living autologous human umbilical cord cell-based septal occluder membranes using composite PGA-P4HB matrices
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Weber, B., Schoenauer, R., Papadopulos, F., Modregger, P., Peter, S., Stampanoni, M., Mauri, A., Mazza, E., Gorelik, J., Agarkova, I., Frese, L., Breymann, C., Kretschmar, O., & Hoerstrup, S. P. (2011). Engineering of living autologous human umbilical cord cell-based septal occluder membranes using composite PGA-P4HB matrices. Biomaterials, 32(36), 9630–9641. https://doi.org/10.1016/j.biomaterials.2011.07.070
Abstract
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Abstract
Interventional closure of intracardiac wall defects using occluder devices has evolved as a highly attractive treatment option. However, incomplete and delayed healing reactions often result in a major risk of residual defects, thromboembolism, or device fractures. Biodegradable living tissue engineered occluder membranes (TEOMs) could provide autologous thromboresistant implants with growth and remodeling capacities. PGA-P4HB composite matrices were seeded with human umbilical cord-derived cells or vascular-derived control cells and
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Creators (Authors)
- Weber, B
- Schoenauer, R
- Papadopulos, F
- Modregger, P
- Peter, S
- Stampanoni, M
- Mauri, A
- Mazza, E
- Gorelik, J
- Agarkova, I
- Frese, L
- Breymann, C
- Kretschmar, O
- Hoerstrup, S P
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Weber, B., Schoenauer, R., Papadopulos, F., Modregger, P., Peter, S., Stampanoni, M., Mauri, A., Mazza, E., Gorelik, J., Agarkova, I., Frese, L., Breymann, C., Kretschmar, O., & Hoerstrup, S. P. (2011). Engineering of living autologous human umbilical cord cell-based septal occluder membranes using composite PGA-P4HB matrices. Biomaterials, 32(36), 9630–9641. https://doi.org/10.1016/j.biomaterials.2011.07.070
