Publication: TGF-β Signalling Regulates Cytokine Production in Inflammatory Cardiac Macrophages during Experimental Autoimmune Myocarditis
TGF-β Signalling Regulates Cytokine Production in Inflammatory Cardiac Macrophages during Experimental Autoimmune Myocarditis
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Tkacz, K., Rolski, F., Stefańska, M., Węglarczyk, K., Szatanek, R., Siedlar, M., Kania, G., & Błyszczuk, P. (2024). TGF-β Signalling Regulates Cytokine Production in Inflammatory Cardiac Macrophages during Experimental Autoimmune Myocarditis. International Journal of Molecular Sciences, 25, 5579. https://doi.org/10.3390/ijms25115579
Abstract
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Abstract
Myocarditis is characterized by an influx of inflammatory cells, predominantly of myeloid lineage. The progression of myocarditis to a dilated cardiomyopathy is markedly influenced by TGF-β signalling. Here, we investigate the role of TGF-β signalling in inflammatory cardiac macrophages in the development of myocarditis and post-inflammatory fibrosis. Experimental autoimmune myocarditis (EAM) was induced in the LysM-Cre × R26-stop-EYFP × Tgfbr2-fl/fl transgenic mice showing impaired TGF-β signalling in the myeloid lineage and the LysM
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- Tkacz, Karolina
- Rolski, Filip
- Stefańska, Monika
- Węglarczyk, Kazimierz
- Szatanek, Rafał
- Siedlar, Maciej
- Kania, Gabriela
- Błyszczuk, Przemysław
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Tkacz, K., Rolski, F., Stefańska, M., Węglarczyk, K., Szatanek, R., Siedlar, M., Kania, G., & Błyszczuk, P. (2024). TGF-β Signalling Regulates Cytokine Production in Inflammatory Cardiac Macrophages during Experimental Autoimmune Myocarditis. International Journal of Molecular Sciences, 25, 5579. https://doi.org/10.3390/ijms25115579
