NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence

Sobecki, Michal; Krzywinska, Ewelina; Nagarajan, Shunmugam; Audigé, Annette; Huỳnh, Khanh; Zacharjasz, Julian; Debbache, Julien; Kerdiles, Yann; Gotthardt, Dagmar; Takeda, Norihiko; Fandrey, Joachim; Sommer, Lukas; Sexl, Veronika; Stockmann, Christian

doi:10.5167/uzh-208853

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Sobecki, M., Krzywinska, E., Nagarajan, S., Audigé, A., Huỳnh, K., Zacharjasz, J., Debbache, J., Kerdiles, Y., Gotthardt, D., Takeda, N., Fandrey, J., Sommer, L., Sexl, V., & Stockmann, C. (2021). NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence. Nature Communications, 12, 4700. https://doi.org/10.1038/s41467-021-25065-w

Abstract

During skin injury, immune response and repair mechanisms have to be coordinated for rapid skin regeneration and the prevention of microbial infections. Natural Killer (NK) cells infiltrate hypoxic skin lesions and Hypoxia-inducible transcription factors (HIFs) mediate adaptation to low oxygen. We demonstrate that mice lacking the Hypoxia-inducible factor (HIF)-1α isoform in NK cells show impaired release of the cytokines Interferon (IFN)-γ and Granulocyte Macrophage - Colony Stimulating Factor (GM-CSF) as part of a blunted immune res