Publication: Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression
Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression
Date
Date
Date
Citations
Dalton, L. E., Kamarashev, J., Barinaga-Rementeria Ramirez, I., White, G., Malliri, A., & Hurlstone, A. (2013). Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression. Journal of Investigative Dermatology, 133, 1572–1581. https://doi.org/10.1038/jid.2013.23
Abstract
Abstract
Abstract
Deregulated Ras signaling initiates and maintains melanocyte neoplasia. The Rho-like GTPase Rac has been implicated in Ras-induced neoplastic transformation. Moreover, a recurrent UV-induced mutation activating RAC1 has recently been detected in human melanoma. Here, a role for Rac in melanoma initiation and progression was investigated in human melanomas and zebrafish models of melanocyte neoplasia. Immunohistochemical analysis revealed RAC expression and activity restricted to melanocytes at the junction of the epidermis and dermis
Metrics
Views
Additional indexing
Creators (Authors)
- Dalton, Lucy E
- Kamarashev, Jivko
- Barinaga-Rementeria Ramirez, Irene
- White, Gavin
- Malliri, Angeliki
- Hurlstone, Adam
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Views
Citations
Dalton, L. E., Kamarashev, J., Barinaga-Rementeria Ramirez, I., White, G., Malliri, A., & Hurlstone, A. (2013). Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression. Journal of Investigative Dermatology, 133, 1572–1581. https://doi.org/10.1038/jid.2013.23
