Publication: Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation
Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation
Date
Date
Date
Citations
Yasmin, N., Bauer, T., Modak, M., Wagner, K., Schuster, C., Köffel, R., Seyerl, M., Stöckl, J., Elbe-Bürger, A., Graf, D., & Strobl, H. (2013). Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation. Journal of Experimental Medicine, 210(12), 2597–2610. https://doi.org/10.1084/jem.20130275
Abstract
Abstract
Abstract
Human Langerhans cell (LC) precursors populate the epidermis early during prenatal development and thereafter undergo massive proliferation. The prototypic antiproliferative cytokine TGF-β1 is required for LC differentiation from human CD34(+) hematopoietic progenitor cells and blood monocytes in vitro. Similarly, TGF-β1 deficiency results in LC loss in vivo. However, immunohistology studies revealed that human LC niches in early prenatal epidermis and adult basal (germinal) keratinocyte layers lack detectable TGF-β1. Here we demonstr
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Yasmin, Nighat
- Bauer, Thomas
- Modak, Madhura
- Wagner, Karin
- Schuster, Christopher
- Köffel, Rene
- Seyerl, Maria
- Stöckl, Johannes
- Elbe-Bürger, Adelheid
- Graf, Daniel
- Strobl, Herbert
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Yasmin, N., Bauer, T., Modak, M., Wagner, K., Schuster, C., Köffel, R., Seyerl, M., Stöckl, J., Elbe-Bürger, A., Graf, D., & Strobl, H. (2013). Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation. Journal of Experimental Medicine, 210(12), 2597–2610. https://doi.org/10.1084/jem.20130275
