Publication: Clinical Relevance of Anti-TNF Antibody Trough Levels and Anti-Drug Antibodies in Treating Inflammatory Bowel Disease Patients
Clinical Relevance of Anti-TNF Antibody Trough Levels and Anti-Drug Antibodies in Treating Inflammatory Bowel Disease Patients
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Reinhold, I., Blümel, S., Schreiner, J., Boyman, O., Bögeholz, J., Cheetham, M., Rogler, G., Biedermann, L., & Scharl, M. (2021). Clinical Relevance of Anti-TNF Antibody Trough Levels and Anti-Drug Antibodies in Treating Inflammatory Bowel Disease Patients. Inflammatory Intestinal Diseases, 6(1), 38–47. https://doi.org/10.1159/000511296
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Background and Aims: The majority of patients treated with anti-tumor necrosis factor (TNF) therapy develop anti-drug antibodies (ADAs), which might result in loss of treatment efficacy. Strict guidelines on measuring trough levels (TLs) and ADA in clinical routine do not exist. To provide real-world data, we took advantage of our tertiary inflammatory bowel disease (IBD) center patient cohort and determined indicators for therapeutic drug monitoring (TDM) and actual consequences in patient care. Methods: We retrospectively collected
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Reinhold, I., Blümel, S., Schreiner, J., Boyman, O., Bögeholz, J., Cheetham, M., Rogler, G., Biedermann, L., & Scharl, M. (2021). Clinical Relevance of Anti-TNF Antibody Trough Levels and Anti-Drug Antibodies in Treating Inflammatory Bowel Disease Patients. Inflammatory Intestinal Diseases, 6(1), 38–47. https://doi.org/10.1159/000511296
