Publication: Wnt/β-Catenin Signaling Pathway Is Necessary for the Specification but Not the Maintenance of the Mouse Retinal Pigment Epithelium
Wnt/β-Catenin Signaling Pathway Is Necessary for the Specification but Not the Maintenance of the Mouse Retinal Pigment Epithelium
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Kim, J.-M., Min, K. W., Kim, Y.-J., Smits, R., Basler, K., & Kim, J. W. (2023). Wnt/β-Catenin Signaling Pathway Is Necessary for the Specification but Not the Maintenance of the Mouse Retinal Pigment Epithelium. Molecules and Cells, 46, 441–450. https://doi.org/10.14348/molcells.2023.0029
Abstract
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Abstract
β-Catenin (Ctnnb1) has been shown to play critical roles in the development and maintenance of epithelial cells, including the retinal pigment epithelium (RPE). Ctnnb1 is not only a component of intercellular junctions in the epithelium, it also functions as a transcriptional regulator in the Wnt signaling pathway. To identify which of its functional modalities is critically involved in mouse RPE development and maintenance, we varied Ctnnb1 gene content and activity in mouse RPE lineage cells and tested their impacts on mouse eye dev
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- Kim, Jong-Myeong
- Min, Kwang Wook
- Kim, You-Joung
- Smits, Ron
- Kim, Jin Woo
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Kim, J.-M., Min, K. W., Kim, Y.-J., Smits, R., Basler, K., & Kim, J. W. (2023). Wnt/β-Catenin Signaling Pathway Is Necessary for the Specification but Not the Maintenance of the Mouse Retinal Pigment Epithelium. Molecules and Cells, 46, 441–450. https://doi.org/10.14348/molcells.2023.0029
