Publication: Evaluation of HIV-1 reservoir size and broadly neutralizing antibody susceptibility in acute antiretroviral therapy-treated individuals
Evaluation of HIV-1 reservoir size and broadly neutralizing antibody susceptibility in acute antiretroviral therapy-treated individuals
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Moldt, B., Günthard, H. F., Workowski, K. A., Little, S. J., Eron, J. J., Overton, E. T., Lehmann, C., Rokx, C., Kozal, M. J., Gandhi, R. T., Braun, D. L., Parvangada, A., Li, J., Martin, R., Selzer, L., Cox, S., Margot, N., Liu, H., Slamowitz, D., … Callebaut, C. (2022). Evaluation of HIV-1 reservoir size and broadly neutralizing antibody susceptibility in acute antiretroviral therapy-treated individuals. AIDS, 36(2), 205–214. https://doi.org/10.1097/QAD.0000000000003088
Abstract
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OBJECTIVE
Persistence of the viral reservoir is the main barrier to curing HIV. Initiation of ART during acute HIV infection can limit the size and diversity of the reservoir. In depth characterization of the reservoir in individuals who initiate ART during acute infection will be critical for clinical trial design and cure strategies.
METHODS
Four cohorts with participants who initiated ART during acute infection or during chronic infection were enrolled in a cross-sectional, noninterventional study. Viral reservoir was evaluated
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Creators (Authors)
- Moldt, Brian
- Günthard, Huldrych F
- Workowski, Kimberly A
- Little, Susan J
- Eron, Joseph J
- Overton, Edgar T
- Lehmann, Clara
- Rokx, Casper
- Kozal, Michael J
- Gandhi, Rajesh T
- Braun, Dominique L
- Parvangada, Aiyappa
- Li, Jiani
- Martin, Ross
- Selzer, Lisa
- Cox, Stephanie
- Margot, Nicolas
- Liu, Hui
- Slamowitz, Debbie
- Makadzange, Tariro
- Collins, Sean E
- Geleziunas, Romas
- Callebaut, Christian
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Citations
Moldt, B., Günthard, H. F., Workowski, K. A., Little, S. J., Eron, J. J., Overton, E. T., Lehmann, C., Rokx, C., Kozal, M. J., Gandhi, R. T., Braun, D. L., Parvangada, A., Li, J., Martin, R., Selzer, L., Cox, S., Margot, N., Liu, H., Slamowitz, D., … Callebaut, C. (2022). Evaluation of HIV-1 reservoir size and broadly neutralizing antibody susceptibility in acute antiretroviral therapy-treated individuals. AIDS, 36(2), 205–214. https://doi.org/10.1097/QAD.0000000000003088