Publication: Scavenger receptor BI promotes cytoplasmic accumulation of lipoproteins in clear-cell renal cell carcinoma
Scavenger receptor BI promotes cytoplasmic accumulation of lipoproteins in clear-cell renal cell carcinoma
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Velagapudi, S., Schraml, P., Yalcinkaya, M., Bolck, H. A., Rohrer, L., Moch, H., & von Eckardstein, A. (2018). Scavenger receptor BI promotes cytoplasmic accumulation of lipoproteins in clear-cell renal cell carcinoma. Journal of Lipid Research, 59(11), 2188–2201. https://doi.org/10.1194/jlr.M083311
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Clear cell renal cell carcinomas (ccRCC) are characterized by inactivation of von Hippel-Lindau (VHL) gene and intracellular lipid accumulation by unknown pathomechanism. The immunochemical analysis of 356 RCCs revealed high abundance of apolipoproteins apoA-I and apoB as well as scavenger receptor BI (SR-BI) in the clear cell RCC subtype. Given the characteristic loss of VHL function in ccRCC, we used VHL-defective and VHL-proficient cells to study the potential influence of VHL on lipoprotein uptake. VHL-defective patient-derived cc
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- Velagapudi, Srividya
- Schraml, Peter
- Yalcinkaya, Mustafa
- Bolck, Hella Anna
- Rohrer, Lucia
- Moch, Holger
- von Eckardstein, Arnold
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Velagapudi, S., Schraml, P., Yalcinkaya, M., Bolck, H. A., Rohrer, L., Moch, H., & von Eckardstein, A. (2018). Scavenger receptor BI promotes cytoplasmic accumulation of lipoproteins in clear-cell renal cell carcinoma. Journal of Lipid Research, 59(11), 2188–2201. https://doi.org/10.1194/jlr.M083311
