Publication: Endoglin and TGF-β signaling in glioblastoma
Endoglin and TGF-β signaling in glioblastoma
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Burghardt, I., Ventura, E., Weiss, T., Schroeder, J. J., Seystahl, K., Zielasek, C., Gramatzki, D., & Weller, M. (2021). Endoglin and TGF-β signaling in glioblastoma. Cell and Tissue Research, 384(3), 613–624. https://doi.org/10.1007/s00441-020-03323-5
Abstract
Abstract
Abstract
Microvascular proliferation is a key feature of glioblastoma and neovascularization has been implicated in tumor progression. Glioblastomas use pro-angiogenic factors such as vascular endothelial growth factor (VEGF) for new blood vessel formation. Yet, anti-VEGF therapy does not prolong overall survival so that alternative angiogenic pathways may need to be explored as drug targets. Both glioma cells and glioma-associated endothelial cells produce TGF-β superfamily ligands which bind TGF-β receptors (TGF-βR). The TGF-βR type III endo
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Creators (Authors)
- Burghardt, Isabel
- Ventura, Elisa
- Weiss, Tobias
- Schroeder, Judith Johanna
- Seystahl, Katharina
- Zielasek, Christian
- Gramatzki, Dorothee
- Weller, Michael
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Burghardt, I., Ventura, E., Weiss, T., Schroeder, J. J., Seystahl, K., Zielasek, C., Gramatzki, D., & Weller, M. (2021). Endoglin and TGF-β signaling in glioblastoma. Cell and Tissue Research, 384(3), 613–624. https://doi.org/10.1007/s00441-020-03323-5
