Publication: Conserved rotavirus NSP5 and VP2 domains interact and affect viroplasm
Conserved rotavirus NSP5 and VP2 domains interact and affect viroplasm
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Buttafuoco, A., Michaelsen, K., Tobler, K., Ackermann, M., Fraefel, C., & Eichwald, C. (2020). Conserved rotavirus NSP5 and VP2 domains interact and affect viroplasm. Journal of Virology, 94(7), e01965-19. https://doi.org/10.1128/jvi.01965-19
Abstract
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Abstract
One step of the life cycle common among all rotaviruses (RV) studied so far is the formation of viroplasms, membrane-less cytosolic inclusions providing a microenvironment for early morphogenesis and RNA replication. Viroplasm-like structures (VLS) are simplified viroplasm models consisting of complexes of non-structural protein 5 (NSP5) with either the RV core-shell VP2 or NSP2. We identified and characterized the domains required for NSP5-VP2 interaction and VLS formation. VP2 mutations L124A, V865A, or I878A impaired both NSP5 hype
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- Buttafuoco, Antonino
- Michaelsen, Kevin
- Tobler, Kurt
- Ackermann, Mathias
- Eichwald, Catherine
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Buttafuoco, A., Michaelsen, K., Tobler, K., Ackermann, M., Fraefel, C., & Eichwald, C. (2020). Conserved rotavirus NSP5 and VP2 domains interact and affect viroplasm. Journal of Virology, 94(7), e01965-19. https://doi.org/10.1128/jvi.01965-19
