The Trw Type IV Secretion System of Bartonella Mediates Host-Specific Adhesion to Erythrocytes

Vayssier-Taussat, Muriel; Le Rhun, Danielle; Deng, Hong Kuan; Biville, Francis; Cescau, Sandra; Danchin, Antoine; Marignac, Geneviève; Lenaour, Evelyne; Boulouis, Henri Jean; Mavris, Maria; Arnaud, Lionel; Yang, Huanming; Wang, Jing; Quebatte, Maxime; Engel, Philipp; Saenz, Henri; Dehio, Christoph

doi:10.1371/journal.ppat.1000946

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Vayssier-Taussat, M., Le Rhun, D., Deng, H. K., Biville, F., Cescau, S., Danchin, A., Marignac, G., Lenaour, E., Boulouis, H. J., Mavris, M., Arnaud, L., Yang, H., Wang, J., Quebatte, M., Engel, P., Saenz, H., & Dehio, C. (2010). The Trw Type IV Secretion System of Bartonella Mediates Host-Specific Adhesion to Erythrocytes. PLoS Pathogens, 6(6), e1000946. https://doi.org/10.1371/journal.ppat.1000946

Abstract

Bacterial pathogens typically infect only a limited range of hosts; however, the genetic mechanisms governing host-specificity are poorly understood. The alpha-proteobacterial genus Bartonella comprises 21 species that cause host-specific intraerythrocytic bacteremia as hallmark of infection in their respective mammalian reservoirs, including the human-specific pathogens Bartonella quintana and Bartonella bacilliformis that cause trench fever and Oroya fever, respectively. Here, we have identified bacterial factors that mediate host-s