Publication: Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype
Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype
Date
Date
Date
Citations
Sinnberg, T., Levesque, M. P., Krochmann, J., Cheng, P. F., Ikenberg, K., Meraz-Torres, F., Niessner, H., Garbe, C., & Busch, C. (2018). Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype. Molecular Cancer, 17(1), 59. https://doi.org/10.1186/s12943-018-0773-5
Abstract
Abstract
Abstract
BACKGROUND During embryonic development Wnt family members and bone morphogenetic proteins (BMPs) cooperatively induce epithelial-mesenchymal transition (EMT) in the neural crest. Wnt and BMPs are reactivated during malignant transformation in melanoma. We previously demonstrated that the BMP-antagonist noggin blocked the EMT phenotype of melanoma cells in the neural crest and malignant invasion of melanoma cells in the chick embryo; vice-versa, malignant invasion was induced in human melanocytes in vivo by pre-treatment with BMP-2.
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Sinnberg, Tobias
- Levesque, Mitchell P
- Krochmann, Jelena
- Ikenberg, Kristian
- Meraz-Torres, Francisco
- Niessner, Heike
- Garbe, Claus
- Busch, Christian
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Sinnberg, T., Levesque, M. P., Krochmann, J., Cheng, P. F., Ikenberg, K., Meraz-Torres, F., Niessner, H., Garbe, C., & Busch, C. (2018). Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype. Molecular Cancer, 17(1), 59. https://doi.org/10.1186/s12943-018-0773-5
