Publication: Cryo-EM structure of the hedgehog release protein dispatched
Cryo-EM structure of the hedgehog release protein dispatched
Date
Date
Date
Citations
Cannac, F., Qi, C., Falschlunger, J., Hausmann, G., Basler, K., & Korkhov, V. M. (2020). Cryo-EM structure of the hedgehog release protein dispatched. Science Advances, 6(16), eaay7928. https://doi.org/10.1126/sciadv.aay7928
Abstract
Abstract
Abstract
The Hedgehog (Hh) signaling pathway controls embryonic development and adult tissue homeostasis in multicellular organisms. In Drosophila melanogaster, the pathway is primed by secretion of a dually lipid-modified morphogen, Hh, a process dependent on a membrane-integral protein Dispatched. Although Dispatched is a critical component of the pathway, the structural basis of its activity has, so far, not been described. Here, we describe a cryo–electron microscopy structure of the D. melanogaster<
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Cannac, Fabien
- Qi, Chao
- Falschlunger, Julia
- Hausmann, George
- Korkhov, Volodymyr M
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Cannac, F., Qi, C., Falschlunger, J., Hausmann, G., Basler, K., & Korkhov, V. M. (2020). Cryo-EM structure of the hedgehog release protein dispatched. Science Advances, 6(16), eaay7928. https://doi.org/10.1126/sciadv.aay7928
