Publication: {beta}1 Integrin Expression Increases Susceptibility of Memory B-Cells to EBV Infection
{beta}1 Integrin Expression Increases Susceptibility of Memory B-Cells to EBV Infection
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Dorner, M., Zucol, F., Alessi, D., Haerle, S. K., Bossart, W., Weber, M., Byland, R., Bernasconi, M., Berger, C., Tugizov, S., Speck, R. F., & Nadal, D. (2010). {beta}1 Integrin Expression Increases Susceptibility of Memory B-Cells to EBV Infection. Journal of Virology, 84(13), 6667–6677. https://doi.org/10.1128/JVI.02675-09
Abstract
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The Epstein-Barr virus (EBV) uses nasopharyngeal-associated lymphoid tissue (NALT) as portal of entry to establish life-long persistence in memory B-cells. We previously showed that naïve and memory B-cells from NALT are equally susceptible to EBV infection. Here, we show that memory B-cells from NALT are significantly more susceptible to EBV infection than those from remote lymphatic organs. We identify beta1 integrin, which is expressed highest by naïve B-cells of distinct lymphoid origin and by memory B-cells from NALT, as mediator
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- Dorner, M
- Zucol, F
- Alessi, D
- Haerle, S K
- Bossart, W
- Weber, M
- Byland, R
- Bernasconi, M
- Tugizov, S
- Speck, R F
- Nadal, D
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Dorner, M., Zucol, F., Alessi, D., Haerle, S. K., Bossart, W., Weber, M., Byland, R., Bernasconi, M., Berger, C., Tugizov, S., Speck, R. F., & Nadal, D. (2010). {beta}1 Integrin Expression Increases Susceptibility of Memory B-Cells to EBV Infection. Journal of Virology, 84(13), 6667–6677. https://doi.org/10.1128/JVI.02675-09
