Characterization of overnight slow-wave slope changes across development in an age-, amplitude-, and region-dependent manner

Jaramillo, Valeria; Volk, Carina; Maric, Angelina; Furrer, Melanie; Fattinger, Sara; Kurth, Salome; Lustenberger, Caroline; Huber, Reto

doi:10.1093/sleep/zsaa038

Citations

Citation copied

Jaramillo, V., Volk, C., Maric, A., Furrer, M., Fattinger, S., Kurth, S., Lustenberger, C., & Huber, R. (2020). Characterization of overnight slow-wave slope changes across development in an age-, amplitude-, and region-dependent manner. Sleep, 43, zsaa038. https://doi.org/10.1093/sleep/zsaa038

Abstract

STUDY OBJECTIVES

The restorative function of sleep has been linked to a net reduction in synaptic strength. The slope of slow-waves, a major characteristic of non-rapid eye movement (NREM) sleep, has been shown to directly reflect synaptic strength, when accounting for amplitude changes across the night. In this study, we aimed to investigate overnight slope changes in the course of development in an age-, amplitude-, and region-dependent manner.

METHODS

All-night high-density electroencephalography data were analyzed in a cross-se