Publication: High-affinity Cu(I) chelator PSP-2 as potential anti-angiogenic agent
High-affinity Cu(I) chelator PSP-2 as potential anti-angiogenic agent
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Heuberger, D. M., Harankhedkar, S., Morgan, T., Wolint, P., Calcagni, M., Lai, B., Fahrni, C. J., & Buschmann, J. (2019). High-affinity Cu(I) chelator PSP-2 as potential anti-angiogenic agent. Scientific Reports, 9, 14055. https://doi.org/10.1038/s41598-019-50494-5
Abstract
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Abstract
Copper is an essential trace metal that has been implicated in angiogenesis, the formation of new blood vessels. As tumor growth relies on establishing a functional capillary network for blood supply, copper chelation therapy may hold promise as an anti-cancer strategy by suppressing angiogenesis. To test the anti-angiogenic effect of PSP-2, a recently developed high affinity Cu(I) chelator with low zeptomolar dissociation constant, we utilized the endothelial cancer cell line EAhy926 and assessed changes in cell migration, proliferat
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- Heuberger, Dorothea M
- Harankhedkar, Shefali
- Morgan, Thomas
- Wolint, Petra
- Calcagni, Maurizio
- Lai, Barry
- Fahrni, Christoph J
- Buschmann, Johanna
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Heuberger, D. M., Harankhedkar, S., Morgan, T., Wolint, P., Calcagni, M., Lai, B., Fahrni, C. J., & Buschmann, J. (2019). High-affinity Cu(I) chelator PSP-2 as potential anti-angiogenic agent. Scientific Reports, 9, 14055. https://doi.org/10.1038/s41598-019-50494-5
