Publication: Mass spectrometric method incorporating enzymatic amplification for attomole-level analysis of target metabolites in biological samples
Mass spectrometric method incorporating enzymatic amplification for attomole-level analysis of target metabolites in biological samples
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Urban, P. L., Amantonico, A., Fagerer, S. R., Gehrig, P., & Zenobi, R. (2010). Mass spectrometric method incorporating enzymatic amplification for attomole-level analysis of target metabolites in biological samples. Chemical Communications, 46(13), 2212–2214. https://doi.org/10.1039/b925433a
Abstract
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Abstract
We report a sensitive method for selective detection of target metabolites from the central metabolic pathway by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS), in which the MS signal is enhanced by up to three orders of magnitude in the course of in situ enzymatic amplification.
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- Urban, P L
- Amantonico, A
- Fagerer, S R
- Gehrig, P
- Zenobi, R
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Urban, P. L., Amantonico, A., Fagerer, S. R., Gehrig, P., & Zenobi, R. (2010). Mass spectrometric method incorporating enzymatic amplification for attomole-level analysis of target metabolites in biological samples. Chemical Communications, 46(13), 2212–2214. https://doi.org/10.1039/b925433a
