Vaccination with Flt3L-induced CD8α+ dendritic cells prevents CD4+ T helper cell-mediated experimental autoimmune myocarditis

Valaperti, Alan; Nishii, Mototsugu; Germano, Davide; Liu, Peter P; Eriksson, Urs

doi:10.1016/j.vaccine.2013.07.084

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Valaperti, A., Nishii, M., Germano, D., Liu, P. P., & Eriksson, U. (2013). Vaccination with Flt3L-induced CD8α+ dendritic cells prevents CD4+ T helper cell-mediated experimental autoimmune myocarditis. Vaccine, 31(42), 4802–4811. https://doi.org/10.1016/j.vaccine.2013.07.084

Abstract

Experimental autoimmune myocarditis (EAM) represents a CD4(+) T helper (Th) cell-mediated mouse model of inflammatory heart disease. Interferon (IFN)-γ, typically produced by Th1 cells, reduces EAM severity in myosin heavy-chain-(MyHC)-α peptide/Complete Freund adjuvant-immunized mice. Thus, developing a vaccination strategy that promotes differentiation of Th1 cells may be beneficial in EAM. FMS-like tyrosine kinase 3 ligand (Flt3L)-induced splenic CD8α(+) dendritic cells (DC), which produce interleukin (IL)-12p35, were identified to