Publication: Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface
Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface
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Roulin, P. S., Lötzerich, M., Torta, F., Tanner, L. B., van Kuppeveld, F. J. M., Wenk, M. R., & Greber, U. F. (2014). Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface. Cell Host & Microbe, 16(5), 677–690. https://doi.org/10.1016/j.chom.2014.10.003
Abstract
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Similar to other positive-strand RNA viruses, rhinovirus, the causative agent of the common cold, replicates on a web of cytoplasmic membranes, orchestrated by host proteins and lipids. The host pathways that facilitate the formation and function of the replication membranes and complexes are poorly understood. We show that rhinovirus replication depends on host factors driving phosphatidylinositol 4-phosphate (PI4P)-cholesterol counter-currents at viral replication membranes. Depending on the virus type, replication required phosphat
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- Roulin, Pascal S
- Lötzerich, Mark
- Torta, Federico
- Tanner, Lukas B
- van Kuppeveld, Frank J M
- Wenk, Markus R
- Greber, Urs F
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Roulin, P. S., Lötzerich, M., Torta, F., Tanner, L. B., van Kuppeveld, F. J. M., Wenk, M. R., & Greber, U. F. (2014). Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface. Cell Host & Microbe, 16(5), 677–690. https://doi.org/10.1016/j.chom.2014.10.003
