Publication: A novel interaction of tRNA(Lys,3) with the feline immunodeficiency virus RNA genome governs initiation of minus strand DNA synthesis.
A novel interaction of tRNA(Lys,3) with the feline immunodeficiency virus RNA genome governs initiation of minus strand DNA synthesis.
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Miller, J. T., Ehresmann, B., Hübscher, U., & Le Grice, S. F. (2001). A novel interaction of tRNA(Lys,3) with the feline immunodeficiency virus RNA genome governs initiation of minus strand DNA synthesis. Journal of Biological Chemistry, 276(29), 27721–27730. https://doi.org/10.1074/jbc.M100513200
Abstract
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Abstract
Complementarity between nucleotides at the 5' terminus of tRNA(Lys,3) and the U5-IR loop of the feline immunodeficiency virus RNA genome suggests a novel intermolecular interaction controls initiation of minus strand synthesis in a manner analogous to other retroviral systems. Base pairing of this tRNA-viral RNA duplex was confirmed by nuclease mapping of the RNA genome containing full-length or 5'-deleted variants of tRNA(Lys,3) hybridized to the primer-binding site. A major pause in RNA-dependent DNA synthesis occurred 14 nucleotide
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- Miller, J T
- Ehresmann, B
- Hübscher, U
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Miller, J. T., Ehresmann, B., Hübscher, U., & Le Grice, S. F. (2001). A novel interaction of tRNA(Lys,3) with the feline immunodeficiency virus RNA genome governs initiation of minus strand DNA synthesis. Journal of Biological Chemistry, 276(29), 27721–27730. https://doi.org/10.1074/jbc.M100513200
