Publication: A chronic high phosphate intake in mice is detrimental for bone health without major renal alterations
A chronic high phosphate intake in mice is detrimental for bone health without major renal alterations
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Ugrica, M., Bettoni, C., Bourgeois, S., Daryadel, A., Pastor-Arroyo, E.-M., Gehring, N., Hernando, N., Wagner, C. A., & Rubio-Aliaga, I. (2021). A chronic high phosphate intake in mice is detrimental for bone health without major renal alterations. Nephrology, Dialysis, Transplantation, 36, 1183–1191. https://doi.org/10.1093/ndt/gfab015
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BACKGROUND
Phosphate intake has increased in the last decades due to a higher consumption of processed foods. This higher intake is detrimental for patients with chronic kidney disease, increasing mortality and cardiovascular disease risk and accelerating kidney dysfunction. Whether a chronic high phosphate diet is also detrimental for the healthy population is still under debate.
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We fed healthy mature adult mice over a period of one year with either a high (1.2% w/w) or a standard (0.6% w/w) phosphate diet, and investigate
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Ugrica, M., Bettoni, C., Bourgeois, S., Daryadel, A., Pastor-Arroyo, E.-M., Gehring, N., Hernando, N., Wagner, C. A., & Rubio-Aliaga, I. (2021). A chronic high phosphate intake in mice is detrimental for bone health without major renal alterations. Nephrology, Dialysis, Transplantation, 36, 1183–1191. https://doi.org/10.1093/ndt/gfab015
