Publication: Heterogeneous regional and temporal energetic impairment following controlled cortical impact injury in rats
Heterogeneous regional and temporal energetic impairment following controlled cortical impact injury in rats
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Thomale, U. W., Griebenow, M., Mautes, A., Beyer, T. F., Dohse, N. K., Stroop, R., Sakowitz, O. W., Unterberg, A. W., & Stover, J. F. (2007). Heterogeneous regional and temporal energetic impairment following controlled cortical impact injury in rats. Neurological Research, 29(6), 594–603. https://doi.org/10.1179/016164107X166272
Abstract
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Abstract
OBJECTIVES: Following traumatic brain injury metabolic stability is impaired. Duration and reversibility of these changes might be important to guide specific interventions. METHODS: To characterize temporal and regional changes in cerebral metabolism, 68 male Sprague-Dawley rats were subjected to a focal cortical contusion. Lesion progression and mitochondrial impairment were determined by magnetic resonance imaging (MRI) and triphenyl tetrazolium chloride (TTC) staining, respectively. Metabolic alterations were determined at hours 6
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- Thomale, U W
- Griebenow, M
- Mautes, A
- Beyer, T F
- Dohse, N K
- Stroop, R
- Sakowitz, O W
- Unterberg, A W
- Stover, J F
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Thomale, U. W., Griebenow, M., Mautes, A., Beyer, T. F., Dohse, N. K., Stroop, R., Sakowitz, O. W., Unterberg, A. W., & Stover, J. F. (2007). Heterogeneous regional and temporal energetic impairment following controlled cortical impact injury in rats. Neurological Research, 29(6), 594–603. https://doi.org/10.1179/016164107X166272
