Publication: Progress in the function and regulation of ADP-Ribosylation
Progress in the function and regulation of ADP-Ribosylation
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Hottiger, M. O., Boothby, M., Koch-Nolte, F., Lüscher, B., Martin, N. M. B., Plummer, R., Wang, Z. Q., & Ziegler, M. (2011). Progress in the function and regulation of ADP-Ribosylation. Science Signaling, 4(174), mr5. https://doi.org/10.1126/scisignal.2001645
Abstract
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Abstract
Adenosine 5'-diphosphate (ADP)-ribosylation is a protein posttranslational modification that is catalyzed by ADP-ribosyltransferases (ARTs), using nicotinamide adenine dinucleotide (NAD(+)) as a substrate. Mono-ribosylation can be extended into polymers of ADP-ribose (PAR). Poly(ADP-ribosyl)polymerase (PARP) 1, the best-characterized cellular enzyme catalyzing this process, is the prototypical member of a family of mono- and poly(ADP-ribosyl)transferases. The physiological consequences of ADP-ribosylation are inadequately understood.
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- Hottiger, M O
- Boothby, M
- Koch-Nolte, F
- Lüscher, B
- Martin, N M B
- Plummer, R
- Wang, Z Q
- Ziegler, M
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Hottiger, M. O., Boothby, M., Koch-Nolte, F., Lüscher, B., Martin, N. M. B., Plummer, R., Wang, Z. Q., & Ziegler, M. (2011). Progress in the function and regulation of ADP-Ribosylation. Science Signaling, 4(174), mr5. https://doi.org/10.1126/scisignal.2001645
