Publication: Long-Range conformational transition of a photoswitchable allosteric protein: Molecular dynamics simulation study
Long-Range conformational transition of a photoswitchable allosteric protein: Molecular dynamics simulation study
Date
Date
Date
Citations
Buchenberg, S., Knecht, V., Walser, R., Hamm, P., & Stock, G. (2014). Long-Range conformational transition of a photoswitchable allosteric protein: Molecular dynamics simulation study. Journal of Physical Chemistry B, 118, 13468–13476. https://doi.org/10.1021/jp506873y
Abstract
Abstract
Abstract
A local perturbation of a protein may lead to functional changes at some distal site. An example is the PDZ2 domain of human tyrosine phosphatase 1E which shows an allosteric transition upon binding to a peptide ligand. Recently Buchli et al. presented a time-resolved study of this transition by covalently linking an azobenzene photoswitch across the binding groove and using a femtosecond laser pulse that triggers the cis-trans photoisomerization of azobenzene. To aid the interpretation of these experiments, in this work seven microse
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Buchenberg, Sebastian
- Knecht, Volker
- Walser, Reto
- Stock, Gerhard
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
Additional Information
Additional Information
Additional Information
OA Status
OA Status
OA Status
Publisher DOI
Metrics
Downloads
Views
Citations
Buchenberg, S., Knecht, V., Walser, R., Hamm, P., & Stock, G. (2014). Long-Range conformational transition of a photoswitchable allosteric protein: Molecular dynamics simulation study. Journal of Physical Chemistry B, 118, 13468–13476. https://doi.org/10.1021/jp506873y
