Botulinum toxin A and B raise blood flow and increase survival of critically ischemic skin flaps

Schweizer, Dennis F; Schweizer, Riccardo; Zhang, Shengye; Kamat, Pranitha; Contaldo, Claudio; Rieben, Robert; Eberli, Daniel; Giovanoli, Pietro; Erni, Dominique; Plock, Jan A

doi:10.1016/j.jss.2013.04.004

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Schweizer, D. F., Schweizer, R., Zhang, S., Kamat, P., Contaldo, C., Rieben, R., Eberli, D., Giovanoli, P., Erni, D., & Plock, J. A. (2013). Botulinum toxin A and B raise blood flow and increase survival of critically ischemic skin flaps. Journal of Surgical Research, 184(2), 1205–1213. https://doi.org/10.1016/j.jss.2013.04.004

Abstract

BACKGROUND: Botulinum toxin (BTX) A and B are commonly used for aesthetic indications and in neuromuscular disorders. New concepts seek to prove efficacy of BTX for critical tissue perfusion. Our aim was to evaluate BTX A and B in a mouse model of critical flap ischemia for preoperative and intraoperative application. METHODS: BTX A and B were applied on the vascular pedicle of an axial pattern flap in mice preoperatively or intraoperatively. Blood flow, tissue oxygenation, tissue metabolism, flap necrosis rate, apoptosis assay, and R