Publication: The effect of N-acetylcysteine on posttraumatic changes after controlled cortical impact in rats
The effect of N-acetylcysteine on posttraumatic changes after controlled cortical impact in rats
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Thomale, U. W., Griebenow, M., Kroppenstedt, S. N., Unterberg, A. W., & Stover, J. F. (2006). The effect of N-acetylcysteine on posttraumatic changes after controlled cortical impact in rats. Intensive Care Medicine, 32(1), 149–155. https://doi.org/10.1007/s00134-005-2845-4
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OBJECTIVE: The antioxidant potential N-Acetylcysteine (NAC) and its improvement of posttraumatic mitrochondrial dysfunction have been reported. This study investigated the effect of NAC on posttraumatic changes after controlled cortical Impact (CCI) injury. DESIGN AND SETTING: Prospective randomized controlled animal study. METHODS: A moderate left focal cortical contusion was induced using CCI. Either NAC (163 mg/kg bw) or physiological saline was administered intraperitoneally immediately and 2 and 4 h after trauma. Blood gases, tem
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- Thomale, U W
- Griebenow, M
- Kroppenstedt, S N
- Unterberg, A W
- Stover, J F
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Thomale, U. W., Griebenow, M., Kroppenstedt, S. N., Unterberg, A. W., & Stover, J. F. (2006). The effect of N-acetylcysteine on posttraumatic changes after controlled cortical impact in rats. Intensive Care Medicine, 32(1), 149–155. https://doi.org/10.1007/s00134-005-2845-4
