Publication: Swiss multicenter study evaluating the efficacy, feasibility and safety of peginterferon-alfa-2a and ribavirin in patients with chronic hepatitis C in official opiate substitution programs
Swiss multicenter study evaluating the efficacy, feasibility and safety of peginterferon-alfa-2a and ribavirin in patients with chronic hepatitis C in official opiate substitution programs
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Fried, R., Monnat, M., Seidenberg, A., Oppliger, R., Schmid, P., Herold, M., Isler, M., Broers, B., Kölliker, C., Schönbucher, P., Frei, M., & Huber, M. (2008). Swiss multicenter study evaluating the efficacy, feasibility and safety of peginterferon-alfa-2a and ribavirin in patients with chronic hepatitis C in official opiate substitution programs. Digestion, 78(2–3), 123–130. https://doi.org/10.1159/000173733
Abstract
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BACKGROUND: Though patients in opiate substitution programs are commonly infected with HCV, due to safety and efficacy concerns, they are rarely treated with interferon and ribavirin. METHODS: In a multicenter study, HCV-infected patients in opiate maintenance treatment programs received 180 microg pegylated interferon-alfa-2a once weekly, plus daily ribavirin for 24 weeks (genotypes 2, 3), or 48 weeks (genotypes 1, 4). RESULTS: Of the 67 patients enrolled, 31 (46%) had HCV genotypes 1 or 4, and 36 (54%) had genotypes 2 or 3. Intent-t
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- Fried, R
- Monnat, M
- Seidenberg, A
- Oppliger, R
- Schmid, P
- Herold, M
- Isler, M
- Broers, B
- Kölliker, C
- Schönbucher, P
- Frei, M
- Huber, M
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Fried, R., Monnat, M., Seidenberg, A., Oppliger, R., Schmid, P., Herold, M., Isler, M., Broers, B., Kölliker, C., Schönbucher, P., Frei, M., & Huber, M. (2008). Swiss multicenter study evaluating the efficacy, feasibility and safety of peginterferon-alfa-2a and ribavirin in patients with chronic hepatitis C in official opiate substitution programs. Digestion, 78(2–3), 123–130. https://doi.org/10.1159/000173733
