Publication: Aberrant methylated key genes of methyl group metabolism within the molecular etiology of urothelial carcinogenesis
Aberrant methylated key genes of methyl group metabolism within the molecular etiology of urothelial carcinogenesis
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Erichsen, L., Ghanjati, F., Beermann, A., Poyet, C., Hermanns, T., Schulz, W. A., Seifert, H.-H., Wild, P. J., Buser, L., Kröning, A., Braunstein, S., Anlauf, M., Jankowiak, S., Hassan, M., Bendhack, M. L., Araúzo-Bravo, M. J., & Santourlidis, S. (2018). Aberrant methylated key genes of methyl group metabolism within the molecular etiology of urothelial carcinogenesis. Scientific Reports, 8(1), 3477. https://doi.org/10.1038/s41598-018-21932-7
Abstract
Abstract
Abstract
Urothelial carcinoma (UC), the most common cancer of the urinary bladder causes severe morbidity and mortality, e.g. about 40.000 deaths in the EU annually, and incurs considerable costs for the health system due to the need for prolonged treatments and long-term monitoring. Extensive aberrant DNA methylation is described to prevail in urothelial carcinoma and is thought to contribute to genetic instability, altered gene expression and tumor progression. However, it is unknown how this epigenetic alteration arises during carcinogenes
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Creators (Authors)
- Erichsen, Lars
- Ghanjati, Foued
- Beermann, Agnes
- Poyet, Cedric
- Hermanns, Thomas
- Schulz, Wolfgang A
- Seifert, Hans-Helge
- Wild, Peter J
- Buser, Lorenz
- Kröning, Alexander
- Braunstein, Stefan
- Anlauf, Martin
- Jankowiak, Silvia
- Hassan, Mohamed
- Bendhack, Marcelo L
- Santourlidis, Simeon
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Erichsen, L., Ghanjati, F., Beermann, A., Poyet, C., Hermanns, T., Schulz, W. A., Seifert, H.-H., Wild, P. J., Buser, L., Kröning, A., Braunstein, S., Anlauf, M., Jankowiak, S., Hassan, M., Bendhack, M. L., Araúzo-Bravo, M. J., & Santourlidis, S. (2018). Aberrant methylated key genes of methyl group metabolism within the molecular etiology of urothelial carcinogenesis. Scientific Reports, 8(1), 3477. https://doi.org/10.1038/s41598-018-21932-7
