Publication: Probiotic Escherichia coli Nissle 1917 and commensal E. coli K12 differentially affect the inflammasome in intestinal epithelial cells
Probiotic Escherichia coli Nissle 1917 and commensal E. coli K12 differentially affect the inflammasome in intestinal epithelial cells
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Becker, H. M., Apladas, A., Scharl, M., Fried, M., & Rogler, G. (2014). Probiotic Escherichia coli Nissle 1917 and commensal E. coli K12 differentially affect the inflammasome in intestinal epithelial cells. Digestion, 89(2), 110–118. https://doi.org/10.1159/000357521
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BACKGROUND: The probiotic bacterial strain Escherichia coli Nissle 1917 (EcN) is used for the treatment of ulcerative colitis (UC), diarrhea and constipation. Its beneficial effects in the treatment of UC have been demonstrated in several controlled clinical studies; however, the mechanism of action on the cellular level is still not completely clear. The intracellular pattern recognition receptor NLRP3 is expressed in intestinal epithelial cells (IEC), activates caspase-1 within the inflammasome complex and has been implicated to pla
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- Becker, Helen M
- Apladas, Aretussa
- Scharl, Michael
- Fried, Michael
- Rogler, Gerhard
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Becker, H. M., Apladas, A., Scharl, M., Fried, M., & Rogler, G. (2014). Probiotic Escherichia coli Nissle 1917 and commensal E. coli K12 differentially affect the inflammasome in intestinal epithelial cells. Digestion, 89(2), 110–118. https://doi.org/10.1159/000357521
