Publication: Elevated CSF histamine levels in multiple sclerosis patients
Elevated CSF histamine levels in multiple sclerosis patients
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Kallweit, U., Aritake, K., Bassetti, C. L., Blumenthal, S., Hayaishi, O., Linnebank, M., Baumann, C. R., & Urade, Y. (2013). Elevated CSF histamine levels in multiple sclerosis patients. Fluids and Barriers of the CNS, 10, 19. https://doi.org/10.1186/2045-8118-10-19
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Abstract
BACKGROUND: Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis. FINDINGS: CSF histamine levels in MS patient samples were significantly higher (median: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with a
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- Kallweit, U
- Aritake, K
- Bassetti, C L
- Blumenthal, S
- Hayaishi, O
- Linnebank, M
- Baumann, C R
- Urade, Y
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Kallweit, U., Aritake, K., Bassetti, C. L., Blumenthal, S., Hayaishi, O., Linnebank, M., Baumann, C. R., & Urade, Y. (2013). Elevated CSF histamine levels in multiple sclerosis patients. Fluids and Barriers of the CNS, 10, 19. https://doi.org/10.1186/2045-8118-10-19
