Publication: Syntheses of high valent fac-[99mTcO3]+ complexes and [2+3] cycloadditions with alkenes in water as a direct labelling strategy
Syntheses of high valent fac-[99mTcO3]+ complexes and [2+3] cycloadditions with alkenes in water as a direct labelling strategy
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Braband, H., Tooyama, Y., Fox, T., & Alberto, R. (2009). Syntheses of high valent fac-[99mTcO3]+ complexes and [2+3] cycloadditions with alkenes in water as a direct labelling strategy. Chemistry, 15, 633–638. https://doi.org/10.1002/chem.200801757
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Reported herein is a new concept for the labelling of biomolecules with small (99m)TcO(3) complexes through a [3+2] cycloaddition with alkenes for radiopharmaceutical applications. We developed convenient reactions for the synthesis of small, water stable fac-TcO(3)(tacn-R) complexes ((99)Tc and (99m)Tc, tacn = 1,4,7-triazacyclononane, R = H, -CH(2)-C(6)H(5), -CH(2)-C(6)H(4)COOH). With alkenes, these high valent (99m)TcO(3) complexes undergo [3+2] cycloaddition with formation of the corresponding Tc(V)-glycolato complex
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- Tooyama, Y
- Fox, T
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Braband, H., Tooyama, Y., Fox, T., & Alberto, R. (2009). Syntheses of high valent fac-[99mTcO3]+ complexes and [2+3] cycloadditions with alkenes in water as a direct labelling strategy. Chemistry, 15, 633–638. https://doi.org/10.1002/chem.200801757
