Publication: Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo
Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo
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Abdel-Mohsen, M., Deng, X., Liegler, T., Guatelli, J. C., Salama, M. S., Ghanem, H. E.-D. A., Rauch, A., Ledergerber, B., Deeks, S. G., Günthard, H. F., Wong, J. K., & Pillai, S. K. (2014). Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo. Journal of Virology, 88(1), 763–767. https://doi.org/10.1128/JVI.02687-13
Abstract
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Abstract
Alpha interferon (IFN-α) suppresses human immunodeficiency virus type 1 (HIV-1) replication in vitro by inducing cell-intrinsic retroviral restriction mechanisms. We investigated the effects of IFN-α/ribavirin (IFN-α/riba) treatment on 34 anti-HIV-1 restriction factors in vivo. Expression of several anti-HIV-1 restriction factors was significantly induced by IFN-α/riba in HIV/hepatitis C virus (HCV)-coinfected individuals. Fold induction of cumulative restriction factor expression in CD4(+) T cells was significantly correlated with vi
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- Abdel-Mohsen, Mohamed
- Deng, Xutao
- Liegler, Teri
- Guatelli, John C
- Salama, Mohamed S
- Ghanem, Hussam El-Din A
- Rauch, Andri
- Ledergerber, Bruno
- Deeks, Steven G
- Günthard, Huldrych F
- Wong, Joseph K
- Pillai, Satish K
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Abdel-Mohsen, M., Deng, X., Liegler, T., Guatelli, J. C., Salama, M. S., Ghanem, H. E.-D. A., Rauch, A., Ledergerber, B., Deeks, S. G., Günthard, H. F., Wong, J. K., & Pillai, S. K. (2014). Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo. Journal of Virology, 88(1), 763–767. https://doi.org/10.1128/JVI.02687-13