Publication: In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510
In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510
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Ishikawa, A., Tokunaga, M., Maeda, J., Minamihisamatsu, T., Shimojo, M., Takuwa, H., Ono, M., Ni, R., Hirano, S., Kuwabara, S., Ji, B., Zhang, M.-R., Aoki, I., Suhara, T., Higuchi, M., & Sahara, N. (2018). In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510. Journal of Alzheimer’s Disease, 61(3), 1037–1052. https://doi.org/10.3233/jad-170509
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Background:Tau imaging using PET is a promising tool for the diagnosis and evaluation of tau-related neurodegenerative disorders, but the relationship among PET-detectable tau, neuroinflammation, and neurodegeneration is not yet fully understood. Objective:We aimed to elucidate sequential changes in tau accumulation, neuroinflammation, and brain atrophy by PET and MRI in a tauopathy mouse model. Methods:rTg4510 transgenic (tg) mice expressing P301L mutated tau and non-tg mice were examined with brain MRI and PET imaging (analyzed numb
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- Ishikawa, Ai
- Tokunaga, Masaki
- Maeda, Jun
- Minamihisamatsu, Takeharu
- Shimojo, Masafumi
- Takuwa, Hiroyuki
- Ono, Maiko
- Ni, Ruiqing
- Hirano, Shigeki
- Kuwabara, Satoshi
- Ji, Bin
- Zhang, Ming-Rong
- Aoki, Ichio
- Suhara, Tetsuya
- Higuchi, Makoto
- Sahara, Naruhiko
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Ishikawa, A., Tokunaga, M., Maeda, J., Minamihisamatsu, T., Shimojo, M., Takuwa, H., Ono, M., Ni, R., Hirano, S., Kuwabara, S., Ji, B., Zhang, M.-R., Aoki, I., Suhara, T., Higuchi, M., & Sahara, N. (2018). In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510. Journal of Alzheimer’s Disease, 61(3), 1037–1052. https://doi.org/10.3233/jad-170509