Publication: Probing the canonicity of the Wnt/Wingless signaling pathway
Probing the canonicity of the Wnt/Wingless signaling pathway
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Franz, A., Shlyueva, D., Brunner, E., Stark, A., & Basler, K. (2017). Probing the canonicity of the Wnt/Wingless signaling pathway. PLoS Genetics, 13(4), e1006700. https://doi.org/10.1371/journal.pgen.1006700
Abstract
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Abstract
The hallmark of canonical Wnt signaling is the transcriptional induction of Wnt target genes by the beta-catenin/TCF complex. Several studies have proposed alternative interaction partners for beta-catenin or TCF, but the relevance of potential bifurcations in the distal Wnt pathway remains unclear. Here we study on a genome-wide scale the requirement for Armadillo (Arm, Drosophila beta-catenin) and Pangolin (Pan, Drosophila TCF) in the Wnt/Wingless(Wg)-induced transcriptional response of Drosophila Kc cells. Using somatic genetics, w
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- Franz, Alexandra
- Shlyueva, Daria
- Brunner, Erich
- Stark, Alexander
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Franz, A., Shlyueva, D., Brunner, E., Stark, A., & Basler, K. (2017). Probing the canonicity of the Wnt/Wingless signaling pathway. PLoS Genetics, 13(4), e1006700. https://doi.org/10.1371/journal.pgen.1006700
