Publication: A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation
A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation
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Cantù, C., Pagella, P., Shajiei, T. D., Zimmerli, D., Valenta, T., Hausmann, G., Basler, K., & Mitsiadis, T. A. (2017). A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation. Science Signaling, 10(465), eaah4598. https://doi.org/10.1126/scisignal.aah4598
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Wnt-stimulated β-catenin transcriptional regulation is necessary for the development of most organs, including teeth. Bcl9 and Bcl9l are tissue-specific transcriptional cofactors that cooperate with β-catenin. In the nucleus, Bcl9 and Bcl9l simultaneously bind β-catenin and the transcriptional activator Pygo2 to promote the transcription of a subset of Wnt target genes. We showed that Bcl9 and Bcl9l function in the cytoplasm during tooth enamel formation in a manner that is independent of Wnt-stimulated β-catenin-dependent transcripti
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- Cantù, Claudio
- Pagella, Pierfrancesco
- Shajiei, Tania D
- Zimmerli, Dario
- Valenta, Tomas
- Hausmann, George
- Mitsiadis, Thimios A
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Cantù, C., Pagella, P., Shajiei, T. D., Zimmerli, D., Valenta, T., Hausmann, G., Basler, K., & Mitsiadis, T. A. (2017). A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation. Science Signaling, 10(465), eaah4598. https://doi.org/10.1126/scisignal.aah4598
