Publication: Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice
Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice
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Zhang, C., Kúkeľová, D., Sigrist, H., Hengerer, B., Kratzer, R. F., Mracek, P., Omrani, A., von Heimendahl, M., & Pryce, C. R. (2024). Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice. Translational Psychiatry, 14(1), 363. https://doi.org/10.1038/s41398-024-03081-w
Abstract
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Abstract
Reward processing dysfunctions e.g., anhedonia, apathy, are common in stress-related neuropsychiatric disorders including depression and schizophrenia, and there are currently no established therapies. One potential therapeutic approach is restoration of reward anticipation during appetitive behavior, deficits in which co-occur with attenuated nucleus accumbens (NAc) activity, possibly due to NAc inhibition of mesolimbic dopamine (DA) signaling. Targeting NAc regulation of ventral tegmental area (VTA) DA neuron responsiveness to rewar
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- Zhang, Chenfeng
- Kúkeľová, Diana
- Sigrist, Hannes
- Hengerer, Bastian
- Kratzer, Ramona F
- Mracek, Philipp
- Omrani, Azar
- von Heimendahl, Moritz
- Pryce, Christopher R
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Zhang, C., Kúkeľová, D., Sigrist, H., Hengerer, B., Kratzer, R. F., Mracek, P., Omrani, A., von Heimendahl, M., & Pryce, C. R. (2024). Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice. Translational Psychiatry, 14(1), 363. https://doi.org/10.1038/s41398-024-03081-w
