Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects

Parker, Helen; Hoad, Caroline L; Tucker, Emily; Costigan, Carolyn; Marciani, Luca; Gowland, Penny; Fox, Mark

doi:10.5167/uzh-161044

Citations

Citation copied

Parker, H., Hoad, C. L., Tucker, E., Costigan, C., Marciani, L., Gowland, P., & Fox, M. (2018). Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects. Neurogastroenterology and Motility, 30, e13463. https://doi.org/10.1111/nmo.13463

Abstract

BACKGROUND Current investigations of gastric emptying rarely identify the cause of symptoms or provide a definitive diagnosis in patients with dyspepsia. This study assessed gastric function by magnetic resonance imaging (MRI) using the modular "Nottingham test meal" (NTM) in healthy volunteers (HVs). METHODS The NTM comprises (a) 400 mL liquid nutrient (0.75 kcal/mL) labeled with Gadolinium-DOTA and (b) an optional solid component (12 agar-beads [0 kcal]). Filling sensations were documented. MRI measurements of gastric volume, emp