Publication: Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity
Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity
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Deuel, J. W., Vallelian, F., Schaer, C. A., Puglia, M., Buehler, P. W., & Schaer, D. J. (2015). Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity. Free Radical Biology & Medicine, 89, 931–943. https://doi.org/10.1016/j.freeradbiomed.2015.09.016
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Free hemoglobin (Hb) triggered vascular damage occurs in many hemolytic diseases, such as sickle cell disease, with an unmet need for specific therapeutic interventions. Based on clinical observations the Hb and heme scavenger proteins haptoglobin (Hp) and hemopexin (Hx) have been characterized as a sequential defense system with Hp as the primary protector and Hx as a backup when all Hp is depleted during more severe intravascular hemolysis. In this study we present a mechanistic rationale for this paradigm based on a combined bioche
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- Deuel, Jeremy W
- Vallelian, Florence
- Schaer, Christian A
- Puglia, Michele
- Buehler, Paul W
- Schaer, Dominik J
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Deuel, J. W., Vallelian, F., Schaer, C. A., Puglia, M., Buehler, P. W., & Schaer, D. J. (2015). Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity. Free Radical Biology & Medicine, 89, 931–943. https://doi.org/10.1016/j.freeradbiomed.2015.09.016
