Publication: Medicine in the Fourth Dimension
Medicine in the Fourth Dimension
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Cederroth, C. R., Albrecht, U., Bass, J., Brown, S. A., Dyhrfjeld-Johnsen, J., Gachon, F., Green, C. B., Hastings, M. H., Helfrich-Förster, C., Hogenesch, J. B., Lévi, F., Loudon, A., Lundkvist, G. B., Meijer, J. H., Rosbash, M., Takahashi, J. S., Young, M., & Canlon, B. (2019). Medicine in the Fourth Dimension. Cell Metabolism, 30, 238–250. https://doi.org/10.1016/j.cmet.2019.06.019
Abstract
Abstract
Abstract
The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This suggests that the biology of the target cell will determine how an organ will respond to a drug at a specific time of the day, thus modulating pharma
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Creators (Authors)
- Cederroth, Christopher R
- Albrecht, Urs
- Bass, Joseph
- Brown, Steven A
- Dyhrfjeld-Johnsen, Jonas
- Gachon, Frederic
- Green, Carla B
- Hastings, Michael H
- Helfrich-Förster, Charlotte
- Hogenesch, John B
- Lévi, Francis
- Loudon, Andrew
- Lundkvist, Gabriella B
- Meijer, Johanna H
- Rosbash, Michael
- Takahashi, Joseph S
- Young, Michael
- Canlon, Barbara
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Cederroth, C. R., Albrecht, U., Bass, J., Brown, S. A., Dyhrfjeld-Johnsen, J., Gachon, F., Green, C. B., Hastings, M. H., Helfrich-Förster, C., Hogenesch, J. B., Lévi, F., Loudon, A., Lundkvist, G. B., Meijer, J. H., Rosbash, M., Takahashi, J. S., Young, M., & Canlon, B. (2019). Medicine in the Fourth Dimension. Cell Metabolism, 30, 238–250. https://doi.org/10.1016/j.cmet.2019.06.019