Regulation of intestinal phosphate transport. II. Metabolic acidosis stimulates Na(+)-dependent phosphate absorption and expression of the Na(+)-P(i) cotransporter NaPi-IIb in small intestine

Stauber, A; Radanovic, T; Stange, G; Murer, H; Wagner, C A; Biber, J

doi:10.1152/ajpgi.00168.2004

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Stauber, A., Radanovic, T., Stange, G., Murer, H., Wagner, C. A., & Biber, J. (2005). Regulation of intestinal phosphate transport. II. Metabolic acidosis stimulates Na(+)-dependent phosphate absorption and expression of the Na(+)-P(i) cotransporter NaPi-IIb in small intestine. American Journal Of Physiology. Gastrointestinal And Liver Physiology, 288(3), G501–G506. https://doi.org/10.1152/ajpgi.00168.2004

Abstract

During metabolic acidosis, P(i) serves as an important buffer to remove protons from the body. P(i) is released from bone together with carbonate buffering protons in blood. In addition, in the kidney, the fractional excretion of phosphate is increased allowing for the excretion of more acid equivalents in urine. The role of intestinal P(i) absorption in providing P(i) to buffer protons and compensating for loss from bone during metabolic acidosis has not been clarified yet. Inducing metabolic acidosis (NH(4)Cl in drinking water) for