Publication: Flanking sequence preference modulates de novo DNA methylation in the mouse genome
Flanking sequence preference modulates de novo DNA methylation in the mouse genome
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Mallona, I., Ilie, I. M., Karemaker, I. D., Butz, S., Manzo, M., Caflisch, A., & Baubec, T. (2021). Flanking sequence preference modulates de novo DNA methylation in the mouse genome. Nucleic Acids Research, 49(1), 145–157. https://doi.org/10.1093/nar/gkaa1168
Abstract
Abstract
Abstract
Mammalian de novo DNA methyltransferases (DNMT) are responsible for the establishment of cell-type-specific DNA methylation in healthy and diseased tissues. Through genome-wide analysis of de novo methylation activity in murine stem cells we uncover that DNMT3A prefers to methylate CpGs followed by cytosines or thymines, while DNMT3B predominantly methylates CpGs followed by guanines or adenines. These signatures are further observed at non-CpG sites, resembling methylation context observed in specialised cell types, including neurons
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- Mallona, Izaskun
- Ilie, Ioana Mariuca
- Karemaker, Ino Dominiek
- Butz, Stefan
- Manzo, Massimiliano
- Caflisch, Amedeo
- Baubec, Tuncay
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Mallona, I., Ilie, I. M., Karemaker, I. D., Butz, S., Manzo, M., Caflisch, A., & Baubec, T. (2021). Flanking sequence preference modulates de novo DNA methylation in the mouse genome. Nucleic Acids Research, 49(1), 145–157. https://doi.org/10.1093/nar/gkaa1168
