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Damage to histaminergic tuberomammillary neurons and other hypothalamic neurons with traumatic brain injury


Valko, P O; Gavrilov, Y V; Yamamoto, M; Finn, K; Reddy, H; Haybaeck, J; Weis, S; Scammell, T E; Baumann, C R (2015). Damage to histaminergic tuberomammillary neurons and other hypothalamic neurons with traumatic brain injury. Annals of Neurology, 77(1):177-182.

Abstract

The need for increased sleep after traumatic brain injury is a common and disabling complaint, yet its etiology is unknown. Previous studies have demonstrated diffuse damage to various hypothalamic systems, but the integrity of the histaminergic tuberomammillary nucleus, a major arousal-promoting system located in the posterior hypothalamus, has never been examined in head trauma patients. Here, we demonstrate that severe head trauma is associated with a marked loss (41%) of histaminergic neurons. Reduced histamine signaling may contribute to increased sleep need, and therapies that enhance histaminergic tone may improve arousal after head trauma or other conditions. ANN NEUROL 2014. © 2014 American Neurological Association.

Abstract

The need for increased sleep after traumatic brain injury is a common and disabling complaint, yet its etiology is unknown. Previous studies have demonstrated diffuse damage to various hypothalamic systems, but the integrity of the histaminergic tuberomammillary nucleus, a major arousal-promoting system located in the posterior hypothalamus, has never been examined in head trauma patients. Here, we demonstrate that severe head trauma is associated with a marked loss (41%) of histaminergic neurons. Reduced histamine signaling may contribute to increased sleep need, and therapies that enhance histaminergic tone may improve arousal after head trauma or other conditions. ANN NEUROL 2014. © 2014 American Neurological Association.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Neurology
Health Sciences > Neurology (clinical)
Language:English
Date:2015
Deposited On:07 Nov 2014 07:58
Last Modified:30 Jul 2020 14:57
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0364-5134
OA Status:Green
Publisher DOI:https://doi.org/10.1002/ana.24298
PubMed ID:25363332

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