Jiricny, J; Menigatti, M (2008). DNA Cytosine demethylation: are we getting close? Cell, 135(7):1167-1169.
Whether 5-methylcytosine (meC) can be enzymatically removed from vertebrate DNA has been the subject of extensive study and also some controversy. Rai et al. (2008) now report that cytosine demethylation can be accomplished in a one-cell zebrafish embryo by the combined action of a cytidine deaminase and a thymine DNA glycosylase.
Whether 5-methylcytosine (meC) can be enzymatically removed from vertebrate DNA has been the subject of extensive study and also some controversy. Rai et al. (2008) now report that cytosine demethylation can be accomplished in a one-cell zebrafish embryo by the combined action of a cytidine deaminase and a thymine DNA glycosylase.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Institute of Molecular Cancer Research
07 Faculty of Science > Institute of Molecular Cancer Research |
| Dewey Decimal Classification: | 570 Life sciences; biology |
| Scopus Subject Areas: | Life Sciences > General Biochemistry, Genetics and Molecular Biology |
| Language: | English |
| Date: | 2008 |
| Deposited On: | 13 Jan 2009 10:26 |
| Last Modified: | 25 Jun 2022 09:26 |
| Publisher: | Elsevier |
| ISSN: | 0092-8674 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1016/j.cell.2008.12.008 |
| PubMed ID: | 19109887 |
Jiricny, J