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In vivo efficacy of apramycin in murine infection models


Meyer, Martin; Freihofer, Pietro; Scherman, Michael; Teague, Joanne; Lenaerts, Anne; Böttger, Erik C (2014). In vivo efficacy of apramycin in murine infection models. Antimicrobial Agents and Chemotherapy, 58(11):6938-6941.

Abstract

Apramycin is a unique aminoglycoside with a dissociation of antibacterial activity and ototoxicity. We assessed the antibacterial efficacy of apramycin in two murine models of infection, Mycobacterium tuberculosis aerosol infection and Staphylococcus aureus septicemia. In both infection models, the efficacy of apramycin was comparable to that of amikacin. These results suggest that apramycin has the potential to become a clinically useful agent against drug-resistant pathogens and support further development of this promising unique aminoglycoside.

Abstract

Apramycin is a unique aminoglycoside with a dissociation of antibacterial activity and ototoxicity. We assessed the antibacterial efficacy of apramycin in two murine models of infection, Mycobacterium tuberculosis aerosol infection and Staphylococcus aureus septicemia. In both infection models, the efficacy of apramycin was comparable to that of amikacin. These results suggest that apramycin has the potential to become a clinically useful agent against drug-resistant pathogens and support further development of this promising unique aminoglycoside.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Microbiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Pharmacology
Health Sciences > Pharmacology (medical)
Health Sciences > Infectious Diseases
Language:English
Date:November 2014
Deposited On:03 Dec 2014 16:37
Last Modified:25 Mar 2020 22:30
Publisher:American Society for Microbiology
ISSN:0066-4804
OA Status:Closed
Publisher DOI:https://doi.org/10.1128/AAC.03239-14
PubMed ID:25136009

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